We use 2-photon live imaging of immune cell interactions to understand the underlying dynamics of the germinal center reaction. Specifically we use 2-photon live imaging to understand how different subsets of T cells shape the germinal center reaction, both in primary and memory responses.

We use photoactivation of specific microanatomical niches to extract and phenotype the T cell subsets involved in the germinal center regulation.

We develop novel transgenic mouse models to study how T cells shape the adaptive immune response.

We use a novel approach termed LIPSTIC (Labeling Immune Partnerships by SorTagging Intercellular Contacts) for labelling and analysing the germinal center resident T cell subsets.

We use our understanding of the germinal center reaction to produce therapeutic monoclonal antibodies with enhanced features.