Our research

A successful defense against pathogens depends on the adaptive behaviour of B cells and T cells. This process occurs in specialized microanatomical structures known as germinal centers (GCs).

Here B cells undergo selection to produce protective antibodies. Protective antibodies can neutralize pathogens.

Conversely, GC B cells can generate antibodies with specificities that target the body's own components. Specialized subsets of T cells regulate the process of B cell selection in the GC.

We aim to understand the contribution of the different T cell subsets to the GC reaction and how this information can be used to tailor an optimal immune response.